Figure 10
From: CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription
Possible mechanisms for positive or negative modification of CLOCK/BMAL1-mediated transcription by CBP. (Left) CBP functions as a coactivator of CLOCK/BMAL1 through an interaction with co-activator pCAF. (Right) CBP functions as a corepressor of CLOCK/BMAL1 through an interaction with co-repressor HDAC3.