Figure 1
From: Plasticity of NMDA receptor NR2B subunit in memory and chronic pain
Genetic overexpression of NMDA NR2B receptors in forebrains enhanced central synaptic potentiation. a. Synaptic potentiation induced by a single tetanic stimulation (100 Hz, 1 sec) was significantly enhanced in NR2B transgenic mice compared with wild-type littermates; b. Enhancement of synaptic potentiation is frequency-dependent, and LTD induced by low-frequency stimulation (1 Hz, 15 min) was not affected din NR2B transgenic mice. Modified from Tang et al (1999). Zhuo's lab contributed to the plasticity studies in this original article.