Figure 5
From: Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats
Anti-allodynic effects by intrathecal administration of fluorocitrate (A) or minocycline (B). On 12 days after Walker 256 inoculation, fluorocitrate (1 nmol), a glia metabolic inhibitor, or minocycline (100 μg), a kind of microglia activation inhibitor significantly increased the mechanical thresholds to von Frey hair stimulation 3 hrs after i.t. treatment. *p < 0.05 vs. normal saline treatment; #p < 0.05 vs. before treatment.