Figure 3
From: Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
GluN2B subunit activity within the ACC is necessary for trace fear learning. (A) Mice exposed to bilateral 0.5 μl infusions into the ACC of either Ro25-6981 (2 μg/μl) or saline 15 minutes prior to trace fear training exhibited similar learning curves. (B) Mice exposed to Ro25-6981 prior to training showed a significant reduction in freezing behavior in response to the CS when tested in a new context 48 h later (saline: n = 4; Ro25-6981: n = 4, t = 3.06). (C) (Left) The memory impairment was still evident one month after training. (Right) Representative markers indicating microinjection locations. (* P < 0.02 ).