Fig. 4

Characterization of modified amino acid pairs in whole temporal lobe proteome of AD + CVD subjects and controls. a Relative intensity areas of deamidated Gln amino acid pairs in the temporal lobe proteome of age-matched controls, women with dementia, and men with dementia. b Relative intensity areas of deamidated Asn amino acid pairs in the temporal lobe proteome of age-matched controls, women with dementia, and men with dementia. c Heat map displaying relative intensity areas of Arg citrullination amino acid pairs in whole temporal lobe proteome of age-matched controls, women with dementia, and men with dementia. In the heat map ratio scale red values indicate up-regulation of the referred amino acid pair and white values indicate no identification. The following amino acid pairs were not susceptible to Arg citrullination in the temporal lobe of human subjects; Arg-Cys, Arg-Lys, Arg-Met, Arg-Gln and Arg-Trp. Significance level between AD + CVD and controls (* p < 0.05; ** p < 0.001)