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Fig. 2 | Molecular Brain

Fig. 2

From: Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression

Fig. 2

ZBD-2-mediated regulation of the HPA axis hormone levels in the PPD models. a-d The CRH (a), ACTH (b), and CORT (c) levels were significantly increased and the 5-HT (d) level was obviously decreased in the sera of PPD models. ZBD-2 reversed the CRH, ACTH, CORT, and 5-HT to basal levels, which were blocked by PK11195 treatment. The effects of ZBD-2 were comparable to the effects of fluoxetine. n = 6 mice in each group. **p < 0.01 compared with the control; #p < 0.05, ##p < 0.01 compared with the PPD model; $$p < 0.01 compared with the ZBD-2 group. PK: PK11195

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Molecular Brain

ISSN: 1756-6606