Fig. 1
From: Pathophysiology of ion channels in amyotrophic lateral sclerosis
Alteration of ion channels along the motor pathway in ALS rodent models and patients. Channels shown in red are downregulated, while channels shown in green are upregulated. CIC1, chloride channel; Kir4.1, inward rectifier potassium channel; Kv1.1/Kv1.2/Kv7.2, voltage-gated potassium channels, Na+/K+-ATPase, sodium/potassium ATPase; Nav1.3/Nav1.4/Nav1.6, voltage-gated sodium channels; NCX3, sodium/calcium exchanger