Fig. 4
From: Involvement of posterior hypothalamic CaMKII-positive neurons in ADHD-like behaviors in mice
Activation of CaMKII + neurons in the PH produces impulsive behavior. (A) Schematic diagram of the cliff avoidance test. (B) The number of jumps down from the cliff was recorded for the hM3Dq-CNO group (n = 11) and the hM3Dq-PBS (n = 21), revealing a statistically significant difference (****p < 0.0001, two-tailed unpaired t-test). (C) After administrating i.p. injection of CNO to mice expressing hM3Dq (hM3Dq-CNO) and performing cliff avoidance test, the same mice were injected with PBS the next day (hM3Dq-PBS), followed by a subsequent cliff avoidance test. There was a significant difference in the number jumping-down behaviors between the groups (n = 6, *p < 0.05, two-tailed paired t-test). (D) Schematic diagram of the rat exposure test. (E) The interaction scores of hM3Dq-PBS (n = 10) and hM3Dq-CNO (n = 7) groups in the rat exposure test (**p < 0.01, two-tailed unpaired t-test). (F) Time hM3Dq-PBS (n = 10) and hM3Dq-CNO (n = 7) mice hung on the net in front of the rat (****p < 0.0001, two-tailed unpaired t-test)