Fig. 4
From: Research progress of brain organoids in the field of diabetes
Applications of brain organoid research. As part of a regenerative medicine therapy, pluripotent stem cells (PSCs) from brain organoids may be implanted to brain injury areas to heal damaged tissue or utilized to investigate brain illnesses. To simulate vascular and infectious disorders and investigate their interactions with organoid cells, non-CNS derived entities including microglia, blood arteries, and viruses may be incorporated into brain organoids. The genesis of disorders affecting the nervous system may be studied using brain organoids obtained from patients or genetically engineered using CRISPR-Cas9 to carry disease-associated genetic abnormalities