Fig. 2

Association of PD susceptibility with ODCs and OPCs. A Multi-marker analysis of genomic annotation (MAGMA) gene set enrichment based on all the 88,876 high quality nuclei showed significant associations with oligodendrocytes (ODCs) and oligodendrocyte precursor cells (OPCs) (see Table S4). B Number of differentially expressed genes (DEGs) in each comparison and cell-type (see Table S5). C MAGMA gene set enrichment based on DEGs in LRRK2 vs HC (upper) and in GBA1 vs HC (lower) (see Table S6). D Gene ontology enrichment analysis of up-regulated (left) or down-regulated (right) genes. Top five biological process terms for each gene list are indicated. Enrichr combined score is calculated by the logarithmic transformation of the p-value obtained from Fisher’s exact test, multiplied by the z-score representing the deviation from the expected rank (see Table S7)