Fig. 1

Significant linear regression plots of resting state fMRI and biomarkers. In the CN group, GAP-43 levels positively correlate with the average to posterior measure (R² = 0.25, p = 0.05). In the MCI group, T_tau and P_Tau levels negatively correlate with both cognitive measures: T_tau vs. average to posterior (R² = 0.39, p = 0.01) and average to ventral (R² = 0.32, p = 0.03), and P_Tau vs. average to posterior (R² = 0.38, p = 0.02) and average to ventral (R² = 0.33, p = 0.03). These R-squared values indicate moderate explanatory power, and the p-values show statistical significance after adjustment