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Table 2 Association between Ramsay sedation score and variants

From: γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam

       

Additive Model

Dominant Model

Recessive Model

      

HWE

            

Gene

Chr

SNP

Position

A1/A2

MAF

P

β

95% CI

P

Q

β

95% CI

P

Q

β

95% CI

P

Q

GABRA1

5

rs10042696

161,879,765

C/T

0.35

0.20

0.10

− 0.14 to 0.35

0.408

0.960

0.16

− 0.15 to 0.48

0.309

0.957

0.03

− 0.49 to 0.55

0.921

0.993

GABRA2

4

rs77166883

46,314,374

T/C

0.18

1

− 0.40

− 0.68 to − 0.12

0.006

0.347

− 0.47

− 0.80 to − 0.15

0.004

0.246

− 0.42

− 1.31 to 0.47

0.357

0.941

GABRA3

X

rs389292

152,372,982

C/T

0.18

1

− 0.26

− 0.58 to 0.06

0.109

0.763

        

GABRA5

15

rs8028947

26,928,735

T/C

0.09

0.17

− 0.35

− 0.71 to 0.02

0.065

0.749

− 0.26

− 0.68 to 0.16

0.229

0.913

− 1.71

− 2.94 to − 0.49

0.007

0.933

GABRB1

4

rs73247636

47,092,489

A/G

0.10

0.13

0.64

0.31 to 0.97

2.1 × 10− 4

0.039

0.72

0.34 to 1.10

3.0 × 10− 4

0.047

1.03

− 0.05 to 2.11

0.064

0.933

  

rs56278524

47,110,636

A/G

0.12

0.15

0.63

0.32 to 0.93

9.4 × 10− 5

0.035

0.73

0.37 to 1.10

1.1 × 10− 4

0.035

0.94

− 0.02 to 1.91

0.058

0.933

GABRB2

5

rs17521304

161,404,861

T/C

0.10

0.10

0.46

0.11 to 0.80

0.010

0.391

0.48

0.08 to 0.89

0.020

0.482

1.03

− 0.05 to 2.11

0.064

0.933

GABRB3

15

rs73368376

26,641,680

A/G

0.09

1

0.38

− 0.01 to 0.76

0.057

0.728

0.37

− 0.04 to 0.77

0.077

0.612

1.30

− 0.84 to 3.44

0.236

0.941

GABRD

1

rs28574670

2,027,822

G/A

0.24

0.24

− 0.08

− 0.32 to 0.17

0.535

0.960

− 0.04

− 0.35 to 0.28

0.816

0.974

− 0.32

− 0.91 to 0.27

0.291

0.941

GABRE

X

rs2266859

151,973,735

A/G

0.47

0.45

− 0.22

− 0.46 to 0.02

0.068

0.749

        

GABRG1

4

rs1353640

46,104,826

A/C

0.33

0.20

0.07

− 0.16 to 0.30

0.539

0.960

0.17

− 0.14 to 0.49

0.278

0.957

− 0.08

− 0.55 to 0.38

0.732

0.993

GABRG2

5

rs11135176

162,095,550

C/T

0.30

0.61

− 0.24

− 0.47 to 0.00

0.047

0.677

− 0.27

− 0.58 to 0.04

0.086

0.633

− 0.40

− 0.91 to 0.12

0.132

0.933

GABRG3

15

rs7173587

27,219,705

C/T

0.09

0.37

− 0.63

− 1.03 to − 0.23

0.002

0.269

− 0.63

− 1.03 to − 0.23

0.002

0.201

NA

NA

NA

NA

GABRQ

X

rs10482208

152,642,426

C/T

0.11

1

0.08

− 0.31 to 0.47

0.679

0.963

        
  1. Variants with lowest P values in each gene and with false discovery rate P < 0.05 are listed. Variants on the X chromosome were excluded from the analyses for the dominant and recessive models. The regression coefficients (β) represent the effect size and direction with the major allele as the reference allele. Values in bold indicate the lowest P values within each gene and significant results with a false discovery rate P < 0.05
  2. Chr, chromosome; SNP, single-nucleotide polymorphism; Position, chromosomal position in Genome Reference Consortium Human Build 38; A1, major allele; A2, minor allele; MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium exact test; β, regression coefficient; Q, false discovery rate P; NA, not available
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