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Fig. 3 | Molecular Brain

Fig. 3

From: Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity

Fig. 3

TTX treatment induces changes in de novo protein synthesis. (A) Volcano plot representing results of homopropargylglycine (HPG)-based stable isotope labeling with amino acids in cell culture (SILAC) analysis. Significantly up- and down-regulated proteins are indicated by colored dots. Five proteins with the highest ⎜log2FC ⎜were labeled in the volcano plot (n = 3 biological replicates in each group; Table S2). (B) g-Profiler analysis of differentially synthesized proteins upon TTX treatment. (C) Correlation of log2FCs from transcriptome and HPG-SILAC analyses. Significantly regulated gene/protein pairs (significance found in both transcriptome and SILAC analysis) are indicated by colored dots (Table S3)

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Molecular Brain

ISSN: 1756-6606