Fig. 1
From: Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications
The SHH pathways in tumorigenesis and their types (canonical and non-canonical). Image was created with https://www.Biorender.com. CNS; Central Nervous System, CDON; Cell Adhesion Associated Oncogene Regulated; BOC; Butoxycarbonyl, GAS; Growth Arrest Specific, PTCH; Patched, SMO; Smoothened, SUFU; Suppressor of Fused; PKA; Protein Kinase A, CTD; C-Terminal Domain, CCNB; Cyclin B, GTPase; Guanosine Triphosphate, SHH; Sonic Hedgehog, RAS; Reticular Activating System, RAF; Rapidly Accelerated Fibrosarcoma, MEK; Mitogen-Activated Protein, ERK; Extracellular-Signal-Regulated kinase, PI3K; Phosphatidylinositol-3 Kinase, AKT; Protein Kinase B, mTOR; Mammalian Target of Rapamycin, TGF-β; Transforming Growth Factor Beta