Fig. 2

NSG2 KO animals display normal motor coordination. (A) The latency to fall from the rotating rod (4-40RPM) is presented. Means from both groups increased significantly across trials but no differences between wt and KO animals were observed. Results are expressed as mean ± SEM. (B) Representative compliant runs of wt (upper) and NSG2 KO (lower) animals depicting automated detection of right front (RF), right hind (RH), left front (LF), and left hind (LH) paws. (C-D) A heat map of transformed data for each trait (column) and mouse (row) were evaluated statistically and are represented as a volcano plot in (D). While several individual traits were found to differ between genotypes (red line p = 0.05), none survived False-Discovery Rate correction (dashed cyan line p = 0.0002). Blue line p = 0.01; green line p = 0.001