Fig. 4

NSG2 KO selectively decreases activity during the active phase. (A) Homecage behavioral monitoring using photocell beam breaks to measure horizontal activity across 48 h. There was a highly significant effect of phase (light vs. dark) where animals showed significantly more activity during dark periods (active phase; p < 0.0001). (B-C) NSG2 KO animals were significantly less active than wild-type animals during the active phase (B; p < 0.05), while no differences were found for the light phase (C; inactive phase, p > 0.05). Results are expressed as mean ± SEM. n = 12/genotype