Fig. 5

Loss of NSG2 causes enhance behavioral flexibility. (A) Schematic of touchscreen-based Discrimination-Reversal Paradigm. Animals are trained to respond to 85% correct for two consecutive sessions in the initial Discrimination before the shape choice is reversed. Early-to-chance reversal is represented as fewer than 50% correct responses, while above 50% correct until criterion (85% over two days) is considered late reversal. (B) Average total trials to reach criterion in Discrimination. (C) Average total trials to reach Criterion in Reversal. (D) Average total trials during early-to-chance reversal (under 50) and average total trials during late reversal (over 50). Each dot represents an individual animal. * indicates p < 0.05, by two-tailed independent t-test in C and mixed-model ANOVA with Bonferroni’s multiple comparisons test in D