Fig. 7
From: Quercetin carbon quantum dots: dual-target therapy for intracerebral hemorrhage in mice
Effects of QECQDs treatment on enhancing the post-ICH microenvironment. (a) Schematic timeline of treatment and analysis following ICH model establishment. Inhibition of Fe2+ (b) and Fe3+ (c) production induced by ICH on day 3 post-QECQDs treatment (n = 5/group, one-way ANOVA). (d) Inhibition of ROS production induced by ICH on day 3 post-QECQDs treatment (n = 5/group, one-way ANOVA). (e) Representative immunofluorescence images illustrating levels of MDA and cleaved caspase-3 in neurons around the hemorrhagic injury site on day 3 post-QECQDs treatment. Neurons are marked by Nissl staining, MDA by FITC, cleaved caspase-3 by TRITC, and nuclei by DAPI. Scale bar, 10 μm. (f, g) Quantification of MDA+ (f) and cleaved caspase-3+ (g) neurons on day 3 post-QECQDs treatment (n = 7/group, one-way ANOVA). (h) Immunoblot bands and (i, j) quantitative analysis illustrating levels of MDA (i) and cleaved caspase-3 (j) in brain tissue 3 days following the QECQDs therapeutic intervention (n = 5/group, one-way ANOVA)