Fig. 2

Novelty exposure gradually increases theta power in specific areas in the HPC-mPFC-VTA circuit. a-c In the mPFC, mice exposed to the novel, but not the familiar, area displayed progressive increases in theta power (a: time x group, P < 0.0001; time, P = 0.09; group, P = 0.08; b: P = 0.3; c: P = 0.008). d-f In the vHPC, the novel group displayed progressive increases in theta power compared with the familiar group (d: time x group, P = 0.003; time, P = 0.08; group, P = 0.01; e: P = 0.8; f: P = 0.008). g-i In the VTA, the novel group showed gradual increases in theta power relative to the familiar group (g: time x group, P = 0.0002; time, P = 0.07; group, P = 0.03; h: P = 0.3; i: P = 0.02). j-l In the dHPC, both groups displayed similar theta power during arena exposure (j: time x group, P = 0.9; time, P = 0.8; group, P = 0.7; k: P = 0.6; l: P = 0.8). Inset: Left, magnification of the area enclosed by dashed lines. Right, average normalized power in the shaded area. Two-way RM ANOVA for (a, d, g, j). Wilcoxon signed-rank test for the rest. N.S., not significant. *P < 0.05, **P < 0.005, ***P < 0.0005. Data are represented as mean ± SEM