Fig. 3

Novelty exposure impacts theta coherence dynamics in specific circuits between the HPC, mPFC, and VTA. a-c The novel, but not the familiar, group exhibited increasing vHPC-mPFC theta coherence during arena exposure (a: time x group, P < 0.0001; time, P = 0.1; group, P = 0.8; b: P = 0.7; c: P = 0.008). d-f The novel group displayed progressive increases in vHPC-VTA theta coherence compared with the familiar group (d: time x group, P = 0.008; time, P = 0.2; group, P = 0.5; e: P = 0.9; f: P = 0.02). g-i The novel group showed gradual increases in VTA-mPFC theta coherence relative to the familiar group (g: time x group, P < 0.0001; time, P = 0.02; group, P = 0.6; h: P = 0.9; i: P = 0.008). j-l In the dHPC, both groups displayed similar theta power during arena exposure (j: time x group, P = 0.9; time, P = 0.9; group, P = 0.5; k: P = 0.9). Within-group analysis between 1- and 10 min revealed increasing theta coherence in the novel group (l: P = 0.04). Inset: average normalized power in the shaded area. Two-way RM ANOVA for (a, d, g, j). Wilcoxon signed-rank test for the rest. N.S., not significant. *P < 0.05, ***P < 0.0005. Data are represented as mean ± SEM