Fig. 6

Antagonizing D1 receptors in the vHPC selectively reduces theta power in the vHPC during novel arena exposure. a-d In the mPFC, mice infused with SCH or vehicle into the vHPC exhibited similar theta power (a: time x group, P = 0.6; time, P < 0.0001; group, P = 0.05; b: P = 0.07; c: P = 0.1; d: SCH, P = 0.02, Veh, P = 0.04). e–h In the vHPC, the SCH group displayed decreased theta power compared with the Veh group (e: time x group, P = 0.2; time, P = 0.0003; group, P = 0.003; f: P = 0.004; g: P = 0.001; h: SCH, P = 0.02, Veh, P = 0.02). i-l In the VTA, both groups of mice showed similar theta power (i: time x group, P = 0.6; time, P = 0.001; group, P = 0.2; j: P = 0.8; k: P = 0.2; l: SCH, P = 0.03, Veh, P = 0.02). m-p In the dHPC, both groups displayed similar theta power during novelty exposure (m: time x group, P = 0.2; time, P = 0.6; group, P = 0.2; n: P = 0.3; o: P = 0.1; p: SCH, P = 0.9, eh, P = 0.8). Inset: magnification of the area enclosed by dashed lines. Two-way RM ANOVA for (a, e, i, m). Mann–Whitney test for between group analysis. Wilcoxon signed-rank test for within group analysis. N.S., not significant. *P < 0.05, **P < 0.005. Data are represented as mean ± SEM