Fig. 7

Antagonizing D1 receptors in the vHPC impacts theta coherence dynamics in specific circuits between the HPC, mPFC, and VTA. a-d The SCH group displayed increased vHPC-mPFC theta coherence compared with the vehicle group. a: time x group, P = 0.7; time, P = 0.01; group, P = 0.02; b: P = 0.02; c: P = 0.07; d: SCH, P = 0.08, Veh, P = 0.02). e–h The SCH group maintained higher vHPC-VTA theta coherence throughout novelty exposure relative to the vehicle group (e: time x group, P = 0.9; time, P = 0.02; group, P = 0.002; f: P = 0.01; g: P = 0.004; h: SCH, P = 0.04, Veh, P = 0.02). i-p Both groups of mice exhibited similar theta coherence in the VTA-mPFC (i: time x group, P = 0.2; time, P = 0.0002; group, P = 0.08; j: P = 0.2; k: P = 0.3; l: SCH, P = 0.02, Veh, P = 0.02), and vHPC-dHPC (m: time x group, P = 0.2; time, P = 0.1; group, P = 0.4; n: P = 0.07; o: P = 0.7; p: SCH, P = 0.03, Veh, P = 0.9). Two-way RM ANOVA for (a, e, i, m). Mann–Whitney test for between-group analysis. Wilcoxon signed-rank test for within-group analysis. N.S., not significant. * P < 0.05, ** P < 0.005. Data are represented as mean ± SEM