Fig. 3
From: Distribution and functional significance of KLF15 in mouse cerebellum
Impaired motor ability in KLF15 cerebellum knockdown mice. A Schematic diagram of 7-day-old cerebellum AAV microinjection (left). The rotarod test measures the balance and coordination ability of a rotating stick on the 21st day after the virus is infected (right). B Compared to the control group, knockdown mice showed a significant decrease in their time spent on the rod before falling. The rod speed at which KLF15 knockdown mice fall from the pole also yielded similar results. C Gait analysis. After 21 days of virus infection, mice were allowed to walk in a narrow 50 cm corridor with ink showing footprints. D Gait analysis statistical results. Compared to the control group, there was no significant difference in step length between the knockdown group and the control group, but the step width significantly narrowed (n = 6). Data are shown as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ns, no significant, vs. control group (two-tailed Student’s t-test)