Skip to main content

Table 2 Multiple linear regression analysis between pH, age at death and disease groups

From: Changes in the pH value of the human brain in Alzheimer’s disease pathology correlated with CD68-positive microglia: a community-based autopsy study in Beijing, China

Variable

Model 1

Model 2

Model 3

Model 4

Model 5

Age at death

-0.003** (0.001)

-0.002* (0.001)

-0.003** (0.001)

-0.003** (0.001)

-0.003** (0.001)

AD

 

-0.095** (0.034)

   

LBDa

  

0.073 (0.045)

  

LATEb

   

0.052 (0.032)

 

PART

    

0.053 (0.034)

n

368

368

356

356

368

adj.R-sq

0.025

0.045

0.033

0.029

0.031

AIC

99.53

93.64

102.3

104.7

99.03

BIC

107.4

105.4

114

116.3

110.8

P value

0.002

< 0.001

0.003

0.005

0.003

  1. Model 1 includes pH and age at death; Model 2 includes pH, age at death and AD; Model 3 includes pH, age at death and LBD; Model 4 includes pH, age at death and LATE; Model 5 includes pH, age at death and PART; Coefficients represent the estimated change in the dependent variable for a one-unit change in the predictor, holding all other predictors constant. Standard Errors are in parentheses. * P<0.05, ** P<0.01, *** P<0.001
  2. Abbreviations: AD, Alzheimer’s disease brain pathology; LBD, Lewy body disease brain pathology; LATE, Limbic predominant age-related TDP-43 encephalopathy; PART, Primary age-related tauopathy, AIC, Akaike information criterion; BIC, Bayesian Information Criterion
  3. a, 12 data missing for LBD group out of the 368 samples
  4. b, 12 data missing for LATE group out of the 368 samples