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Fig. 2 | Molecular Brain

Fig. 2

From: Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism

Fig. 2

Preferential transcellular recruitment of axonal alpha-Nrxn1 by Nlgn2 in non-neuronal cells. A. Co-culture of cortical neurons expressing alpha-Nrxn1 (-AS4) or alpha-Nrxn1 (AS4) with HEK293T cells expressing GFP, Nlgn1 or Nlgn2, as indicated. Expression of alpha-Nrxn1 splice isoforms in neurons and Nlgn1/2 in non-neuronal cells was detected with Flag and VSV antibodies, respectively. B. Quantification of the alpha-Nrxn1 (-AS4) and alpha-Nrxn1 (AS4) signals recruited at contact sites induced by Nlgn1 and Nlgn2. Note that alpha-Nrxn1 isoforms are preferentially recruited by Nlgn2. The insertion of AS4 decreased the recruitment of alpha-Nrxn1 by Nlgn2. Scale bar, 5 μm for Nlgn1 and Nlgn2 and 6,85 μm for GFP transfections

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Molecular Brain

ISSN: 1756-6606