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Fig. 5 | Molecular Brain

Fig. 5

From: Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism

Fig. 5

Selective association of a mutant beta-Nrxn1 protein with Nlgn1 in a mouse model of autism. A. Mutant beta-Nrxn1 was immunoprecipitated from the cortex of control and transgenic mice with increasing amounts of a HA antibody. The immunoprecipitates (IP) and the cleared supernatants (SN) were probed with HA and Nlgn1 antibodies, as shown. B, C. HA-immunoprecipitates from cortex (B) and striatum (C) of control and beta-Nrxn1ΔC adult mice were incubated with antibodies against HA, Nlgn1, Nlgn2, Nlgn3 and LRRTM2, as indicated. As a control, immunoprecipitation was performed in buffer alone (buff). Representative data from three (cortex) or two (striatum) independent experiments are shown. Averaged Nlgn1 levels in the co-immunoprecipitates as percentage of total Nlgn1 in the initial lysates: 5,01 ± 0,71 (cortex), and 1,74 ± 1,41 (striatum)

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Molecular Brain

ISSN: 1756-6606