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Fig. 6 | Molecular Brain

Fig. 6

From: Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition

Fig. 6

Normal CTA acquisition and impaired CTA extinction in mice manipulated with proBDNF-EPE. A: Representative Scheme showing injections sites, timeline of experiment and CTA protocol used for behavioral testing. B: Mice injected with the proBDNF-EPE LV display higher aversion index compared to the control group as of the fifth day of the extinction trial. The aversion index was defined as [ml water/ (ml water + ml saccharin) x100] consumed. Higher aversion index indicates that mice preferred water over saccharin. GFP group (n = 19), BDNF-EPE group (n = 16). Data are presented as mean ± SEM (RM Two-way ANOVA, Extinction Day 4: GFP control versus proBDNF-EPE: p = 0.0655. Extinction Day 5: GFP control versus BDNF-EPE: p < 0.0001. Extinction Day 7: GFP control versus BDNF-EPE: p < 0.0001)

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Molecular Brain

ISSN: 1756-6606