Fig. 4
PRV676 and PRV829 Cre-dependently express fluorescent protein and produce progeny viruses in brain. (A) and (B) The PRV676 (9.3 × 109 PFU/ml, 300 nl) was separately injected into the VTA of the C57BL/6J mice and DAT-Cre mice. (A). The C57BL/6J mice infected with the PRV676 survived through the experimental stage, while DAT-Cre mice infected by PRV676 was dead by 6 dpi (B). (C) and (D) The PRV829 (1.8 × 109 PFU/ml, 300 nl) was separately injected into the VTA of the C57BL/6J mice and DAT-Cre mice. The mRuby3 was only observed in neurons expressing Cre (C). The C57BL/6J mice infected with the PRV829 survived through the experimental stage, while DAT-Cre mice infected by the PRV829 was dead by 6 dpi (D)