Fig. 6
From: GAS reduced inflammatory responses in activated microglia by regulating the Ccr2/Akt/Gsk-3β pathway
GAS inhibits the expression of inflammatory factors TNF-α and IL-1β through the Ccr2/Akt/Gsk-3β pathway. A RS102895 did not cause significant BV2 cell death in the 0 ~ 200 ng/mL range by CCK8. B Western blotting showed that the phosphorylation levels of Akt and Gsk-3β were significantly increased and the expression levels of TNF-α and IL-1β were significantly decreased in the OGD + RS102895 group compared with the OGD group. There were no significant differences in the expression of p-Akt, p-Gsk-3β, TNF-α, and IL-1β in the OGD + RS102895 + GAS group compared with the OGD + RS102895 group. C Presents the protein content in BV2 cells. n = 3, *P < 0.05, ***P < 0.001