Fig. 2

The TNFα inhibitor etanercept abrogates disruption of hippocampal LTP caused by oTau but not SτAs. (a, b) Co-injection of etanercept (Etn, 50 µg, i.c.v.) prevented the inhibition of LTP by i.c.v. injection of synaptotoxic oTau (12.3 pmol). Open triangle: injection of Vehicle, oTau or Etanercept + oTau. (c, d) Injection of etanercept (Etn, 50 µg, i.c.v.) did not prevent the inhibition of LTP caused by i.c.v. injection of SτAs (1.2 pmol, n = 4 pre-injected and n = 2 co-injected). Open triangle: injection of either Vehicle, SτAs or Etn co-injected with SτAs. Open triangle in parentheses: in a subset of experiments Etn was pre-injected 15 min before SτAs. Values are mean ± SEM. ^#p < 0.05, ^##p < 0.01 compared with pre-HFS baseline, paired t-test; **p < 0.01, ***p < 0.001 one-way ANOVA followed by Bonferroni’s multiple-comparison tests