Fig. 4
From: Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo
SτAs prevent oTau-facilitated LTD. Animals received two separate i.c.v. injections (open triangles) either vehicle (Veh), oTau (12.3 pmol, a dose that facilitates LFS300-1 Hz-induced LTD) or oTau and SτAs (0.6 pmol, a dose that blocks LFS300-1 Hz-induced LTD) with the injection sequence roughly counterbalanced (oTau + SτAs, three animals receiving SτAs first and the other two getting oTau first) before applying the weak induction protocol, LFS300-1 Hz. Values in right hand panel at 3 h post-LFS from left hand panel. Values are mean ± SEM. #p < 0.05 compared with pre-LFS baseline, paired t-test; ***p < 0.001 one-way ANOVA followed by Bonferroni’s multiple-comparison tests