Fig. 4
From: Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction
In trace fear conditioning, post-conditioning SD accelerated extinction. (A1) Male S mice (n = 10) showed mild decreases in freezing on Day 2 and strong decreases on Day 18. Male SD mice (n = 10) exhibited decreased freezing on Day 2 with further decreases on Day 18 (*p < 0.05 and **p < 0.01 for S mice, #p < 0.05 and ##p < 0.01 for SD mice, multiple paired t-tests vs. initial 4 trials on Day 2). (A2) Female S mice (n = 10) decreased freezing from Day 2 with further decreases on Day 18. Female SD mice (n = 9) showed strong decreases in freezing on Day 2 to levels comparable to Day 18. (*p < 0.05 and **p < 0.01 for S mice, #p < 0.05 and ##p < 0.01 for SD mice, multiple paired t-tests vs. initial 4 trials on Day 2). (B) SD decreased freezing on later Day 2 (B3) with no significant sex differences from Day 1 (B1), early (B2) and late (B3) Day 2, Day 17 (B4), to early (B5) and late (B6) Day18. (*p < 0.05 for state factor, two-way ANOVA, Table 2). Values represent the mean ± SEM